Changes in motor unit action potentials during the fatigue test

Abstract

The studies were performed on medial gastrocnemius motor units of the rat. Changes in amplitude, duration and latency of motor unit action potentials were monitored in the course of fatigue test in the three types of motor unites: FF (fast twitch, fatigable), FR (fast twitch, resistant), and S (slow twitch, resistant) motor unit. In a majority of the motor units the amplitude of action potential decreased. The most pronounced decrease took place in FF units, less pronounced one in FR units, while in S type motor units the decrease was insignificant. However, in a part of investigated motor units the amplitude of their action potential transiently increased at the beginning of the fatigue test and, then decreased or was maintained at the same level till the end of the fatigue test. In a few motor units, particularly the slow ones, no changes in action potential amplitude were observed. In the studied material, a decrease in action potential amplitude was on the average less pronounced than a decrease in tetanus tension in the course of the fatigue test. In a majority of studied motor units the duration of action potential was becoming prolonged, which was most pronounced in FF type motor units and least pronounced in S type ones. In few slow motor units the duration showed no alterations. Changes in action potential duration were much more marked than changes in their amplitude. The changes in action potential in fast motor units were less pronounced than changes in their tetanus tension, while in the slow motor units they resembled each other in intensity. Comparison of motor unit action potential changes with changes in their tetanic tension in the course of fatigue test demonstrated no clear-cut relationship between the two phenomena.