Vol. 36 No. 3 (1976), Articles
Vol. 36 No. 3 (1976)

The effect of leukocyte-induced degradation products of albumin on the analgesic action of morphine

Articles
M Zarebski
Department of Pharmacology and Research Radiobiological Center School of Medicine, Bialystok, Poland
W Sobaniec
Department of Pharmacology and Research Radiobiological Center School of Medicine, Bialystok, Poland
J Moniuszko-Jakoniuk
Department of Pharmacology and Research Radiobiological Center School of Medicine, Bialystok, Poland
J Maćkowiak
Department of Pharmacology and Research Radiobiological Center School of Medicine, Bialystok, Poland

Abstract

The effect of leukocyte-induced human albumin degradation products (LPAD) on the analgesic potency of morphine was investigated. The degradation products given alone to the rats did not affect pain threshold; while combined with morphine, they potentiated its analgesic action. Moreover, the degradation products increased the concentration of morphine in the brain tissue.
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Copyright (c) 1976 Acta Neurobiologiae Experimentalis

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