Vol. 71 No. 4 (2011), Articles
Vol. 71 No. 4 (2011)

Testosterone and its metabolites - modulators of brain functions

Articles
Published 2011-12-31
Jaroslava Durdiakova
Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia, Email: petercelec@gmail.com; , Institute of Physiology, Comenius University, Bratislava, Slovakia;
Daniela Ostatnikova
Institute of Physiology, Comenius University, Bratislava, Slovakia;
Peter Celec
Institute of Molecular Biomedicine, Comenius University, Bratislava, Slovakia, Email: petercelec@gmail.com; , Institute of Pathophysiology, Comenius University, Bratislava, Slovakia; , Department of Molecular Biology, Comenius University, Bratislava, Slovakia
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Abstract

Testosterone is a steroid sex hormone with an important role in the physiology in both sexes. It is involved in the development of morphological and functional parameters of the body via multiple molecular mechanisms. Intensive research focused on testosterone reveals associations with cognitive abilities and behavior and its causative role in sex differences in cognition. Testosterone modulates brain structure and the differentiation of neurons during intrauterine development with profound effects on brain functions during postnatal life. In this review we summarize the effects of testosterone on brain physiology and cognition with respect to the underlying molecular mechanisms.
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Copyright (c) 2011 Acta Neurobiologiae Experimentalis

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