Vol. 70 No. 3 (2010), Articles
Vol. 70 No. 3 (2010)

Activation of PKC-alpha is required for migration of C6 glioma cells

Articles
Published 2010-09-30
Jian-Guo
Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China; , Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China;
Xiao-Fei
Department of Clinical Laboratory Science, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China;
Jian-Sheng
Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China;
Feng-Chao
Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China;
Xing-Wu
Department of Clinical Laboratory Science, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China;
He-Zuo
Anhui Key Laboratory of Tissue Transplantation, Bengbu Medical College, Bengbu, China; , Central laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China; Email: jghu.hzlv@yahoo.com
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Abstract

The PKC signaling pathway has been implicated in diverse cellular functions. Here, we sought to investigate the role of PKC-alpha/beta in C6 glioma cell migration. We found that both PKC-alpha and PKC-beta were expressed by C6 glioma cells, but only PKC-alpha was markedly activated in serum-treated C6 cells. Gö6976, a PKC-alpha/beta specific inhibitor, was found to cause a dose-dependent reduction of PKC-alpha activation and cell migration induced by serum in C6 cells. These results collectively indicated that the PKC-alpha signaling pathway is necessary for glioma cell migration. Our findings may provide an insight into a better understanding to the malignant progression of gliomas.
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Copyright (c) 2010 Acta Neurobiologiae Experimentalis

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