Vol. 66 No. 2 (2006), Articles
Vol. 66 No. 2 (2006)

Mitochondrial DNA in pathogenesis of Alzheimer's and Parkinson's diseases

Articles
Published 2006-06-30
Aleksandra Maruszak
Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warszawa, Poland;
Katarzyna Gaweda-Walerych
Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warszawa, Poland; , Department of Biology, Central Forensic Laboratory of the Police, Iwicka 14, 00-735 Warszawa, Poland;
Ireneusz Soltyszewski
Department of Criminalistics and Forensic Medicine, University of Warmia and Mazury, Warszawska 98, 10-702 Olsztyn, Poland;
and Zekanowski
Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawińskiego 5, 02-106 Warszawa, Poland; , Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology, Trojdena 4, 02-109 Warszawa, Poland
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Abstract

A critical role of mitochondrial dysfunction and oxidative damage has been implicated in etiopathology of many neurodegenerative disorders, as well as in normal aging. Alzheimer's and Parkinson's diseases are common devastating late-onset neurodegenerative disorders, associated with mitochondrial DNA variations, which are suggested to affect mitochondrial functions. This paper reviews the current knowledge on the inherited and somatic mtDNA variations in both conditions. The correspondence should be addressed to A. Maruszak, Email: ola.maruszak@cmdik.pan.pl
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Copyright (c) 2006 Acta Neurobiologiae Experimentalis

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