Effects of risperidone on auditory information processing in neuroleptic-naive patients with schizophrenia spectrum disorders

Milena Korostenskaja; Kastysis Dapsys; Aldona Siurkute; Valentinas Maciulis; Osvaldas Ruksenas; and Kähkönen

doi:10.55782/ane-2006-1600

Vol. 66 No. 2 (2006), Articles

Vol. 66 No. 2 (2006)

Effects of risperidone on auditory information processing in neuroleptic-naive patients with schizophrenia spectrum disorders

Articles

Published 2006-06-30

Milena Korostenskaja⁺⁻
Kastysis Dapsys⁺⁻
Aldona Siurkute⁺⁻
Valentinas Maciulis⁺⁻
Osvaldas Ruksenas⁺⁻
and Kähkönen⁺⁻

Milena Korostenskaja

Department of Electrophysiology, Republican Vilnius Psychiatric Hospital, Parko-15, Vilnius, Lithuania, LT-11205; , Department of Biochemistry and Biophysics, Vilnius University, Èiurlionio 21/27, Vilnius, Lithuania, LT03101; , BioMag Laboratory, Helsinki University Central Hospital, P. O. Box 340, 00029 HUS, Helsinki, Finland; , Cognitive Brain Research Unit, Department of Psychology, Helsinki University, Siltavuorenpenger 20C, P.O. BOX 9, Helsinki, 00014 Finland; , Department of Psychology, Faculty of Pedagogy and Psychology, Vilnius Pedagogical University, Studentu g. 39, Vilnius, Lithuania, LT-08106 Vilnius, Lithuania

Kastysis Dapsys

Department of Electrophysiology, Republican Vilnius Psychiatric Hospital, Parko-15, Vilnius, Lithuania, LT-11205; , Department of Biochemistry and Biophysics, Vilnius University, Èiurlionio 21/27, Vilnius, Lithuania, LT03101;

Aldona Siurkute

Department of Electrophysiology, Republican Vilnius Psychiatric Hospital, Parko-15, Vilnius, Lithuania, LT-11205;

Valentinas Maciulis

Department of Electrophysiology, Republican Vilnius Psychiatric Hospital, Parko-15, Vilnius, Lithuania, LT-11205;

Osvaldas Ruksenas

Department of Biochemistry and Biophysics, Vilnius University, Èiurlionio 21/27, Vilnius, Lithuania, LT03101;

and Kähkönen

BioMag Laboratory, Helsinki University Central Hospital, P. O. Box 340, 00029 HUS, Helsinki, Finland; , Cognitive Brain Research Unit, Department of Psychology, Helsinki University, Siltavuorenpenger 20C, P.O. BOX 9, Helsinki, 00014 Finland;

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Abstract

Early effects of risperidone (2.5 ± 1 mg/day) on auditory information processing were investigated in 9 neuroleptic naive patients with schizophrenia spectrum disorders and 9 healthy controls by using eventrelated potentials (ERPs). ERPs were elicited during active auditory oddball paradigm and were recorded before and after two weeks of treatment. Baseline P3 latencies were significantly delayed in patient group. Risperidone treatment did not change P3 amplitudes and latencies. However, P2 amplitudes were reduced in parallel with the clinical improvement measured by Positive and Negative Syndrome Scale (PANSS). Although risperidone did not change neural bases of active attention after two weeks of treatment, the reduction of P2 amplitude suggests that risperidone may affect auditory information processing in patients with schizophrenia spectrum disorders who never have been exposed to antipsychotic treatment. The correspondence should be addressed to M. Korostenskaja, Email: milena@rvpl.lt

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