Vol. 64 No. 1 (2004), Articles
Vol. 64 No. 1 (2004)

Genetic aspects of Alzheimer's disease

Articles
Published 2004-03-31
Cezary Zekanowski
Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, 4 Trojdena St. , 02-109 Warsaw, Poland; , Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego St., 02-106 Warsaw, Poland;
Dorota Religa
Department of Neurodegenerative Disorders, Medical Research Centre, Polish Academy of Sciences, 5 Pawińskiego St., 02-106 Warsaw, Poland; , Karolinska Institutet, Neurotec, Novum, level 4, 141 86 Stockholm, Sweden;
Caroline Graff
Karolinska Institutet, Neurotec, Novum, level 5, 141 57 Huddinge, Sweden;
Slawomir Filipek
Laboratory of Biomodelling, International Institute of Molecular and Cell Biology in Warsaw, 4 Trojdena St., 02-109 Warsaw, Poland;
Jacek Kuznicki
Laboratory of Neurodegeneration, International Institute of Molecular and Cell Biology in Warsaw, 4 Trojdena St. , 02-109 Warsaw, Poland; , Laboratory of Calcium Binding Proteins, Nencki Institute of Experimental Biology, 3 Pasteura St., 02-093 Warsaw, Poland
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Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder with a complex etiology and pathogenesis. Mutations in presenilin 1 gene (PSEN1), located on chromosome 14, more rarely in amyloid-? protein precursor (APP) on chromosome 21, and presenilin 2 genes (PSEN2) on chromosome 1, underlie the pathogenesis of most cases of familial early onset of AD (EOAD). The genetics of late-onset AD (LOAD) have been more enigmatic and the only confirmed risk factor for LOAD remains the apolipoprotein E4 allele (ApoE4) on chromosome 19. In this review, we discuss the genetics of AD with a focus on the role of the APP and presenilins.
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Copyright (c) 2004 Acta Neurobiologiae Experimentalis

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