Vol. 59 No. 4 (1999), Articles
Vol. 59 No. 4 (1999)

Lidocaine inhibits neurite growth in mouse dorsal root ganglion cells in culture

Articles
Published 1999-12-31
Hiromi Hiruma
Department of Physiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Email: hiruma@med.kitasato-u.ac.jp;
Hiroshi Maruyama
Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara, 228-8555;
Zyun'ici Simada
Phonetics Laboratory, Kitasato University School of Allied Health Sciences, Sagamihara, 228-8555;
Takashi Katakura
Department of Physiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Email: hiruma@med.kitasato-u.ac.jp;
Sumio Hoka
Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara, 228-8555;
Toshifumi Takenaka
Faculty of Physical Education, Kokushikan University, Tokyo, 206-0025, Japan
Tadashi Kawakami
Department of Physiology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, 228-8555, Email: hiruma@med.kitasato-u.ac.jp;
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Abstract

Recent clinical and experimental studies suggest the effectiveness of lidocaine in blocking neuropathic pain. Because it has been demonstrated that the pathogenetic mechanisms of neuropathic pain involve morphological changes in afferent neuronal terminals onto spinal cord, we examined the effects of lidocaine on neurite growth in isolated mouse dorsal root ganglion cells in culture. Incubation for 2–42 h with various concentrations of lidocaine (0.006 mM, 0.6 mM, and 30 mM) reduced the number of cells exhibiting neurites. The effects were time- and dose-dependent. Lidocaine therefore may exert its pharmacological effect, at least in part, by changing neuronal structures derived from sensory neurons.
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Copyright (c) 1999 Acta Neurobiologiae Experimentalis

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