Bicuculline, AP-7 and behavioral activity in rats

Abstract

The effects of bicuculline (0.25 mg/kg i.p.) and AP-7 (5 nmols icv) on the processes of retrieval, consolidation of conditioned reflexes, object recognition and locomotor activity were tested in rats. Neither AP-7, nor bicuculline nor AP-7 with bicuculline changed locomotor and exploratory activity in the open field test. Co-administration of AP-7 with bicuculline however, facilitated retrieval of passive avoidance in rats, but was without effect on consolidation in this test. Also neither AP-7 nor bicuculline when were given alone had an effect on influenced consolidation. We found no differences in effects of either AP-7 or bicuculline on object recognition regardless whether administered alone or in combination.