Vol. 57 No. 3 (1997), Articles
Vol. 57 No. 3 (1997)

CGP 421 12A abolishes facilitation of recognition caused by angiotensin I1 and angiotensin II(3-7) in rats

Articles
Published 1997-09-30
Jan Braszko
Department of Pharmacology, Medical Academy of Białystok, 2c Mickiewicz St., 15-222 Białystok; , Clinical Pharmacology Unit, Medical Academy of Białystok, 17 Waszyngton St., 15-269 Bialystok, Poland
Alina Kułakowska
Department of Pharmacology, Medical Academy of Białystok, 2c Mickiewicz St., 15-222 Białystok;
Maria Winnicka
Department of Pharmacology, Medical Academy of Białystok, 2c Mickiewicz St., 15-222 Białystok;
Wiesława Karwowska-Polecka
Department of Pharmacology, Medical Academy of Białystok, 2c Mickiewicz St., 15-222 Białystok;
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Abstract

The role of the angiotensin AT2 receptors in some behavioural effects of angiotensin II (Ang II) and its 3-7 fragment [Ang II(3-7)], using their selective antagonist CGP 42112A, was assessed. Ang II and Ang II(3-7), given intracerebroventricularly (icv) at the dose of 1 nmole each, substantially improved object recognition memory and enhanced apomorphine (l mg/kg) stereotypy. Pre-treatment of rats with CGP 42112A (2 micrograms), per se ineffective in all tests, abolished activity of both peptides. None of the treatments significantly changed behaviour of rats in open field. The results point to the considerable involvement of the AT2 angiotensin receptors in the improvement of recognition memory caused by Ang II and Ang II(3-7).
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Copyright (c) 1997 Acta Neurobiologiae Experimentalis

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