Vol. 56 No. 1 (1996), Articles
Vol. 56 No. 1 (1996)

Thyrotropin-releasing hormone (TRH) inhibits vasopressin and oxytocin release from rat hypothalamo- neurohypophysial explants in vitro

Articles
Published 1996-03-31
Joanna Ciosek
Department of Pathophysiology, Medical University of Łódź, 60 Narutowicz St. 90-136 Łódź , Poland
Bożena Stempniak
Department of Pathophysiology, Medical University of Łódź, 60 Narutowicz St. 90-136 Łódź , Poland
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Abstract

Incubation of hypothalamo-neurohypophysial explants in Locke's solution containing 28 nM/L thyrotropin-releasing hormone (TRH) resulted in an inhibition of vasopressin and oxytocin secretion during depolarization due to excess potassium. These data suggest the involvement of TRH in the regulatory mechanisms of vasopressin and oxytocin release; the inhibitory effect of TRH cannot be excluded.
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Copyright (c) 1996 Acta Neurobiologiae Experimentalis

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