Vol. 55 No. 3 (1995), Articles
Vol. 55 No. 3 (1995)

The effect of vasopressin analogue [d(CH2)5(1),Tyr(Me)2]AVP on memory process in rats with experimental amnesia

Articles
Published 1995-09-30
Halina Car
Department of Pharmacology, Medical Academy, 2c Mickiewicz St., 15-222 Białystok, Poland
Maria Borawska
Department of Pharmacology, Medical Academy, 2c Mickiewicz St., 15-222 Białystok, Poland
Konstanty Wiśniewski
Department of Pharmacology, Medical Academy, 2c Mickiewicz St., 15-222 Białystok, Poland

Abstract

We investigated the effect of a single 2 microgram dose of vasopressin (AVP) analogue [d(CH2)5(1),Tyr(Me)2]AVP on the processes of retrieval of conditioned reflexes in rats with experimentally induced amnesia. The models used were: electroconvulsive shock (ECS) and hypoxia. It severely impaired the memory processes. The AVP analogue [d(CH2)5(1),Tyr(Me)2]AVP facilitated retrieval of passive avoidance in all animals.
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Copyright (c) 1995 Acta Neurobiologiae Experimentalis

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